61 papers
HIV/AIDS research remains a critical frontier in global health, focusing on everything from understanding how the virus interacts with the human immune system to developing new treatments and vaccines. This field is constantly evolving, with scientists working tirelessly to improve patient outcomes and move closer to a functional cure. Because these discoveries happen rapidly, staying updated with the latest findings is essential for both experts and the public.
At Gist.Science, we bridge the gap between complex research and clear understanding by processing every new preprint in this category directly from medRxiv. We transform these dense scientific documents into both plain-language explanations and detailed technical summaries, ensuring that the latest insights into HIV and AIDS are accessible to everyone. Below are the most recent papers we have analyzed, offering a fresh look at the ongoing fight against the virus.
This study demonstrates that in people with HIV, biologically informed genetic data transformations—specifically polygenic risk scores and AlphaGenome-derived gene-level impact scores—significantly improve multi-omic prediction accuracy for coronary artery disease and chronic kidney disease compared to using raw SNP genotypes or principal components.
This study presents a machine learning framework combining Random Forest feature selection, association rule mining, and k-prototype clustering to identify key drivers and distinct risk profiles of virological failure among children living with HIV in Malawi, offering a solution to overcome delays in the country's resource-constrained treatment monitoring system.
This study reveals a decade-long divergence in Mozambique among people who inject drugs, characterized by a significant decline in HIV prevalence alongside a sharp, geographically and demographically varied increase in hepatitis C virus prevalence, underscoring the urgent need for differentiated harm-reduction strategies and expanded HCV services.
This study successfully translated, culturally adapted, and validated the HIV/AIDS Stigma and Discrimination Scale for Chinese university students, demonstrating that the resulting 14-item instrument possesses strong reliability and validity for assessing stigma levels among undergraduates.
This study of over 2 million HIV patients in Tanzania reveals that early registry discontinuity is common and geographically linked to population mobility, suggesting that many apparent losses to follow-up actually reflect administrative gaps in tracking mobile patients across facilities rather than true disengagement from care.
This study provides the first comparative analysis of direct implementation costs for oral pills, the dapivirine ring, and long-acting injectable cabotegravir PrEP in Lesotho and Zimbabwe, revealing that while injectable CAB PrEP is the most expensive option, these findings offer critical client-level data to guide HIV prevention budgeting and policy decisions amidst decreasing international funding.
This study of 52,828 people living with HIV across Tanzania's 26 mainland regions reveals significant geographic variation in loss to follow-up and identifies poor pharmacy refill adherence as the strongest independent predictor of disengagement from care, highlighting the value of integrating spatial and refill-based monitoring for targeted retention strategies.
In a two-year Kenyan study of people who inject drugs on dolutegravir-based antiretroviral therapy, approximately one-third experienced viral non-suppression, with living in improvised shelters identified as a significant risk factor, while dolutegravir resistance mutations remained rare despite frequent NNRTI resistance.
This retrospective cohort study at Lira Regional Referral Hospital found that while early infant diagnosis uptake among HIV-exposed infants was sub-optimal compared to national targets, timely administration of cotrimoxazole was significantly associated with the timely completion of the diagnosis process.
This retrospective cohort study of 37,642 patients in Njombe, Tanzania, reveals that 35.6% were lost to follow-up between 2017 and 2021, with significant predictors including poor pharmacy refill adherence, being single or divorced, and residing in the Wangingombe district, while the 2021 cohort showed improved retention.